| Rank | Title | Weekend | Gross |
|---|---|---|---|
| 1. | The Da Vinci Code (2006) | $77.1M | $77.1M |
| 2. | Over the Hedge (2006) | $38.5M | $38.5M |
| 3. | Mission: Impossible III (2006) | $11.3M | $104M |
| 4. | Poseidon (2006) | $9.22M | $36.8M |
| 5. | RV (2006) | $5M | $50.3M |
| 6. | See No Evil (2006) | $4.58M | $4.58M |
| 7. | Just My Luck (2006) | $3.38M | $10.5M |
| 8. | An American Haunting (2005) | $1.48M | $13.4M |
| 9. | United 93 (2006) | $1.4M | $28.3M |
| 10. | Akeelah and the Bee (2006) | $1.01M | $15.7M |
