| Rank | Title | Weekend | Total Gross |
| 1 | Big Momma's House 2 | $ 27.7 m | $ 27.7 m |
| 2 | Nanny McPhee | $ 14.5 m | $ 14.5 m |
| 3 | Underworld: Evolution | $ 11.4 m | $ 44.6 m |
| 4 | Annapolis | $ 7.68 m | $ 7.68 m |
| 5 | Hoodwinked | $ 7.48 m | $ 37.8 m |
| 6 | Brokeback Mountain | $ 6.54 m | $ 51 m |
| 7 | Glory Road | $ 5.35 m | $ 34.9 m |
| 8 | Last Holiday | $ 4.8 m | $ 32.6 m |
| 9 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | $ 4.5 m | $ 278 m |
| 10 | The Metador | $ 3.61 m | $ 5.27 m |
